Nitrogen-Containing Flavonoids-Preparation and Biological Activity 2024 Laboratoř biotransformacíHurtová M.Brdová D.Křížkovská B.Tedeschi G.Nejedlý T.Strnad O.Dobiasová S.Osifová Z.KroneislovÁ G.Lipov J.Valentová K.Viktorová J.Křen V.ACS Omega. 2024; 9(32); 34938-3495010.1021/acsomega.4c04627
Quercetin protects cardiomyoblasts against hypertonic cytotoxicity by abolishing intracellular CaSUP2+/SUP elevations and mitochondrial depolarisation 2024 Laboratoř biotransformacíDostál Z.Zholobenko A.Přichystalová H.Gottschalk B.Valentová K.Malli R.Modrianský M.Biochemical Pharmacology. 2024; 222(April 2024); 11609410.1016/j.bcp.2024.116094
Flavonoids as Aglycones in Retaining Glycosidase-Catalyzed Reactions: Prospects for Green Chemistry 2023 Laboratoř biotransformacíKotík M.Kulik N.Valentová K.Journal of Agricultural and Food Chemistry. 2023; 71(41); 14890-1491010.1021/acs.jafc.3c04389
Farmaceutický přípravek pro léčbu lékově rezistentních bakteriálních infekcí 2023 Laboratoř biotransformacíViktorová J.Křen V.Holasová K.Macek T.Valentová K.Biedermann D.Dobiasová S.
Inhibition of xanthine oxidase-catalyzed xanthine and 6-mercaptopurine oxidation by luteolin; naringenin; myricetin; ampelopsin and their conjugated metabolites 2023 Laboratoř biotransformacíBalazs O.Dombi A.Zsido B.Hetenyi C.Valentová K.Vida R.Poor M.Biomedicine & Pharmacotherapy. 2023; 167(NOV 2023); 11554810.1016/j.biopha.2023.115548
Combination of plant phenolics and isoquinolinium alkaloids protects gingival fibroblast and improves post-extraction healing after lower third molar extraction 2023 Laboratoř biotransformacíChytilová K.Galandaková A.Valentová K.Tvrdý P.Biomedical Papers. 2023; 167(2); 131-13810.5507/bp.2021.055
Biotransformation of Natural Products and Phytochemicals: Metabolites; Their Preparation; and Properties 2023 Laboratoř biotransformacíValentová K.International Journal of Molecular Sciences. 2023; 24(9); 803010.3390/ijms24098030
Metabolic profiling of silymarin constituents in urine and feces of healthy volunteers: A 90-day study 2023 Laboratoř biotransformacíLněničková K.Vrba J.Kosina P.Papoušková B.Mekadim C.Mrázek J.Sova M.Sovová E.Valentová K.Křen V.Kouřilová P.Vrbková J.Ulrichová J.Journal of Functional Foods. 2023; 100(Jan 23); 10539110.1016/j.jff.2022.105391
Selectively Halogenated Flavonolignans—Preparation and Antibacterial Activity 2022 Laboratoř biotransformacíHurtová M.Káňová K.Dobiasová S.Holasová K.Čáková D.Hoang L.Biedermann D.Kuzma M.Cvačka J.Křen V.Viktorová J.Valentová K.International Journal of Molecular Sciences. 2022; 23(23); 1512110.3390/ijms232315121
Sulfation of Phenolic Acids: Chemoenzymatic vs. Chemical Synthesis 2022 Laboratoř biotransformacíKolaříková V.Brodsky K.Petrásková L.Pelantová H.Cvačka J.Havlíček L.Křen V.Valentová K.International Journal of Molecular Sciences. 2022; 23(23); 1517110.3390/ijms232315171
New Bacterial Aryl Sulfotransferases: Effective Tools for Sulfation of Polyphenols 2024 Laboratoř biotransformacíBrodsky K.Petránková B.Petrásková L.Pelantová H.Křen V.Valentová K.Bojarová P.Journal of Agricultural and Food Chemistry. 2024; 72(40); 22208-2221610.1021/acs.jafc.4c06771
Interaction of myricetin; ampelopsin (dihydromyricetin); and their sulfate metabolites with serum albumin; cytochrome P450 (CYP2C9; 2C19; and 3A4) enzymes; and organic anion-transporting polypeptides (OATP1B1 and OATP2B1) 2024 Laboratoř biotransformacíDombi A.Kaci H.Valentová K.Bakos E.Ozvegy-Laczka C.Poór M.Pharmacology Research & Perspectives. 2024; 12(5); e7002110.1002/prp2.70021
The 2-aminoethyl diphenylborinate-based fluorescent method identifies quercetin and luteolin metabolites as substrates of Organic anion transporting polypeptides; OATP1B1 and OATP2B1 2024 Laboratoř biotransformacíKaci H.Bakos E.Needs P.Kroon P.Valentová K.Poor M.Ozvegy-Laczka C.European Journal of Pharmaceutical Sciences. 2024; 196(1 May 2024); 10674010.1016/j.ejps.2024.106740
Bacterial Aryl Sulfotransferases in Selective and Sustainable Sulfation of Biologically Active Compounds using Novel Sulfate Donors 2022 Laboratoř biotransformacíBrodsky K.Káňová K.Konvalinková D.Slámová K.Pelantová H.Valentová K.Bojarová P.Křen V.Petrásková L.ChemSusChem. 2022; 15(18); e20220125310.1002/cssc.202201253
Silybin and its congeners: from traditional medicine to molecular effects 2022 Laboratoř biotransformacíKřen V.Valentová K.Natural Product Reports. 2022; 39(6); 1264-128110.1039/d2np00013j
Interaction of Flavonoids with Zinc and Zinc-Containing Enzymes 2022 Laboratoř biotransformacíHrubša M.Tvrdý V.Kutý M.Valentová K.Křen V.Mladěnka P.Journal of Agricultural and Food Chemistry. 2022; 70(20); 6134-614410.1021/acs.jafc.2c01446
Sulfated Phenolic Substances: Preparation and Optimized HPLC Analysis 2022 Laboratoř biotransformacíPetrásková L.Káňová K.Brodsky K.Hetman A.Petránková B.Pelantová H.Křen V.Valentová K.International Journal of Molecular Sciences. 2022; 23(10); 574310.3390/ijms23105743
Flavonolignans from silymarin modulate antibiotic resistance and virulence in Staphylococcus aureus 2022 Laboratoř biotransformacíHolasová K.Křížkovská B.Hoang L.Dobiasová S.Lipov J.Macek T.Křen V.Valentová K.Ruml T.Viktorová J.Biomedicine & Pharmacotherapy. 2022; 149(May 2022); 11280610.1016/j.biopha.2022.112806
Preparation of Synthetic and Natural Derivatives of Flavonoids Using Suzuki-Miyaura Cross-Coupling Reaction 2022 Laboratoř biotransformacíHurtová M.Biedermann D.Osifová Z.Cvačka J.Valentová K.Křen V.Molecules. 2022; 27(3); 96710.3390/molecules27030967
Silymarin dehydroflavonolignans chelate zinc and partially inhibit alcohol dehydrogenase 2021 Laboratoř biotransformacíTvrdý V.Hrubša M.Jirkovský E.Biedermann D.Kutý M.Valentová K.Křen V.Mladěnka P.Nutrients. 2021; 13(12); 423810.3390/nu13124238
Continuous diastereomeric kinetic resolution—silybins a and b 2021 Laboratoř biotransformacíBiedermann D.Hurtová M.Benada O.Valentová K.Biedermannová L.Křen V.Catalysts. 2021; 11(9); 110610.3390/catal11091106
Flavonols and Flavones 2021 Laboratoř biotransformacíNunes dos Santos C.Menezes R.Carregosa D.Valentová K.In: TOMÁS-BARBERÁN; F.A.; GONZÁLEZ-SARRÍAS; A.; GARCÍA-VILLALBA; R.; eds. Dietary Polyphenols: Metabolism and Health Effects. Hoboken; New Jersey: John Willey and Sons Inc.; 2021; s. 163-198
Flavonolignans from silymarin do not intercalate into DNA: Rebuttal of data published in the paper J. Mol. Recognit. e2812 (2019) 2021 Laboratoř biotransformacíBiedermann D.Hurtová M.Biedermannová L.Valentová K.Křen V.Journal of Molecular Recognition. 2021; 34(7); 288810.1002/jmr.2888
Systematic review of pharmacokinetics and potential pharmacokinetic interactions of flavonolignans from silymarin 2021 Laboratoř biotransformacíTvrdý V.Pourová J.Jirkovský E.Křen V.Valentová K.Mladěnka P.Medicinal Research Reviews. 2021; 41(4); 2195-224610.1002/med.21791
Data sharing in PredRet for accurate prediction of retention time: Application to plant food bioactive compounds 2021 Laboratoř biotransformacíLow D.Micheau P.Koistinen V.Hanhineva K.Abranko L.Rodriguez-Mateos A.da Silva A.van Poucke C.Almeida C.Andres-Lacueva C.Rai D.Capanoglu E.Barberan F.Mattivi F.Schmidt G.Gurdeniz G.Valentová K.Bresciani L.Petrásková L.Dragsted L.Philo M.Ulaszewska M.Mena P.Gonzalez-Dominguez R.Garcia-Villalba R.Kamiloglu S.de Pascual-Teresa S.Durand S.Wiczkowski W.Bronze M.Stanstrup J.Manach C.Food Chemistry. 2021; 357(SEP 30 2021); 12975710.1016/j.foodchem.2021.129757
Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network 2021 Laboratoř biotransformacíVinarov Z.Abrahamsson B.Artursson P.Batchelor H.Berben P.Bernkop-Schnurch A.Butler J.Ceulemans J.Davies N.Dupont D.Flaten G.Fotaki N.Griffin B.Jannin V.Keemink J.Kesisoglou F.Koziolek M.Kuentz M.Mackie A.Melendez-Martinez A.McAllister M.Mullertz A.O'Driscoll C.Parrott N.Paszkowska J.Pávek P.Porter C.Reppas C.Stillhart C.Sugano K.Toader E.Valentová K.Vertzoni M.De Wildt S.Wilson C.Augustijns P.Advanced Drug Delivery Reviews. 2021; 171(APR 2021); 289-33110.1016/j.addr.2021.02.001
Dehydroflavonolignans from Silymarin Potentiate Transition Metal Toxicity In Vitro but Are Protective for Isolated Erythrocytes Ex Vivo 2021 Laboratoř biotransformacíLomozová Z.Tvrdý V.Hrubša M.Catapano M.Macáková K.Biedermann D.Kučera R.Křen V.Mladěnka P.Valentová K.Antioxidants. 2021; 10(5); 67910.3390/antiox10050679
Interaction of silymarin components and their sulfate metabolites with human serum albumin and cytochrome P450 (2C9; 2C19; 2D6; and 3A4) enzymes 2021 Laboratoř biotransformacíFaisal Z.Mohos V.Fliszar-Nyul E.Valentová K.Káňová K.Lemli B.Kunsagi-Mate S.Poor M.Biomedicine & Pharmacotherapy. 2021; 138(JUN 2021); 11145910.1016/j.biopha.2021.111459
Cytoprotective Activity of Natural and Synthetic Antioxidants 2020 Laboratoř biotransformacíValentová K.Antioxidants. 2020; 9(8); 71310.3390/antiox9080713
Sulfated Metabolites of Luteolin; Myricetin; and Ampelopsin: Chemoenzymatic Preparation and Biophysical Properties 2020 Laboratoř biotransformacíKáňová K.Petrásková L.Pelantová H.Rybková Z.Malachová K.Cvačka J.Křen V.Valentová K.Journal of Agricultural and Food Chemistry. 2020; 68(40); 11197-1120610.1021/acs.jafc.0c03997
Multidrug Resistance Modulation Activity of Silybin Derivatives and Their Anti-Inflammatory Potential 2020 Laboratoř biotransformacíDobiasová S.Řehořová K.Kučerová D.Biedermann D.Káňová K.Petrásková L.Koucká K.Václavíková R.Valentová K.Ruml T.Macek T.Křen V.Viktorová J.Antioxidants. 2020; 9(5); 45510.3390/antiox9050455
Identification of Human Sulfotransferases Active towards Silymarin Flavonolignans and Taxifolin 2020 Laboratoř biotransformacíVrba J.Papoušková B.Kosina P.Lněničková K.Valentová K.Ulrichová J.Metabolites. 2020; 10(8); 32910.3390/metabo10080329
Simple and Rapid HPLC Separation and Quantification of Flavonoid; Flavonolignans; and 2;3-Dehydroflavonolignans in Silymarin 2020 Laboratoř biotransformacíPetrásková L.Káňová K.Biedermann D.Křen V.Valentová K.Foods. 2020; 9(2); 11610.3390/foods9020116
Defying Multidrug Resistance! Modulation of Related Transporters by Flavonoids and Flavonolignans 2020 Laboratoř biotransformacíChambers C.Viktorová J.Řehořová K.Biedermann D.Turková L.Macek T.Křen V.Valentová K.Journal of Agricultural and Food Chemistry. 2020; 68(7); 1763-177910.1021/acs.jafc.9b00694
Biotransformation of Silymarin Flavonolignans by Human Fecal Microbiota 2020 Laboratoř biotransformacíValentová K.Havlík J.Kosina P.Papoušková B.Jaimes J.Káňová K.Petrásková L.Ulrichová J.Křen V.Metabolites. 2020; 10(1); 2910.3390/metabo10010029
Protective Effects of Dietary Polyphenols on Arterial Stiffness 2019 Laboratoř biotransformacíHermans N.Steenput B.Roth L.De Meyer G.Nunes dos Santos C.Valentová K.Dambrova M.De Bruyne T.In: DIEDRICH; M.; ed. Proceedings. Basel: MDPI; 201910.3390/proceedings2019011040
The effect of silymarin flavonolignans and their sulfated conjugates on platelet aggregation and blood vessels ex vivo 2019 Laboratoř biotransformacíPourová J.Applová L.Macáková K.Vopršalová M.Migkos T.Bentanachs R.Biedermann D.Petrásková L.Tvrdý V.Hrubša M.Karlíčková J.Křen V.Valentová K.Mladěnka P.Nutrients. 2019; 11(10); 228610.3390/nu11102286
2;3-Dehydroderivatives of Silymarin Flavonolignans: Prospective Natural Compounds for the Prevention of Chronic Diseases 2019 Laboratoř biotransformacíValentová K.Biedermann D.Křen V.Proceedings. 2019; 11(1); 2110.3390/proceedings2019011021
Antioxidant; Anti-Inflammatory; and Multidrug Resistance Modulation Activity of Silychristin Derivatives 2019 Laboratoř biotransformacíViktorová J.Dobiášová S.Řehořová K.Biedermann D.Káňová K.Šeborová K.Václavíková R.Valentová K.Ruml T.Křen V.Macek T.Antioxidants. 2019; 8(8); 30310.3390/antiox8080303
Chemoenzymatic Synthesis and Radical Scavenging of Sulfated Hydroxytyrosol; Tyrosol; and Acetylated Derivatives 2019 Laboratoř biotransformacíBegines P.Biedermann D.Valentová K.Petrásková L.Pelantová H.Maya I.Fernandez-Bolanos J.Křen V.Journal of Agricultural and Food Chemistry. 2019; 67(26); 7281-728810.1021/acs.jafc.9b01065
Preparation of Retinoyl-Flavonolignan Hybrids and Their Antioxidant Properties 2019 Laboratoř biotransformacíChambers C.Biedermann D.Valentová K.Petrásková L.Viktorová J.Kuzma M.Křen V.Antioxidants. 2019; 8(7); 23610.3390/antiox8070236
Glycosidase-Catalyzed Synthesis of Glycosyl Esters and Phenolic Glycosides of Aromatic Acids 2019 Laboratoř biotransformacíBassanini I.Kapešová J.Petrásková L.Pelantová H.Markošová K.Rebroš M.Valentová K.Kotík M.Káňová K.Bojarová P.Cvačka J.Turková L.Ferrandi E.Bayout I.Riva S.Křen V.Advanced Synthesis & Catalysis. 2019; 361(11); 2627-263710.1002/adsc.201900259
The mechanisms of pharmacokinetic food-drug interactions – A perspective from the UNGAP group 2019 Laboratoř biotransformacíKoziolek M.Alcaro S.Augustijns P.Basit A.Grimm M.Hens B.Hoad C.Jedamzik P.Madla C.Maliepaard M.Marciani L.Maruca A.Parrott N.Pávek P.Porter C.Reppas C.van Riet-Nales D.Rubbens J.Statelova M.Trevaskis N.Valentová K.Vertzoni M.Cepo D.Corsetti M.European Journal of Pharmaceutical Sciences. 2019; 134(JUN 15); 31-5910.1016/j.ejps.2019.04.003
Dietary Polyphenols Targeting Arterial Stiffness: Interplay of Contributing Mechanisms and Gut Microbiome-Related Metabolism 2019 Laboratoř biotransformacíDe Bruyne T.Steenput B.Roth L.De Meyer G.Nunes dos Santos C.Valentová K.Dambrova M.Hermans N.Nutrients. 2019; 11(3); 57810.3390/nu11030578
Oxidation of flavonolignan silydianin to unexpected lactone-acid derivative 2019 Laboratoř biotransformacíBiedermann D.Moravcová V.Valentová K.Kuzma M.Petrásková L.Císařová I.Křen V.Phytochemistry Letters. 2019; 30(APR); 14-2010.1016/j.phytol.2019.01.006
Isolated Silymarin Flavonoids Increase Systemic and Hepatic Bilirubin Concentrations and Lower Lipoperoxidation in Mice 2019 Laboratoř biotransformacíŠuk J.Jašprová J.Biedermann D.Petrásková L.Valentová K.Křen V.Muchová L.Vítek L.Oxidative Medicine and Cellular Longevity. 2019; 2019(1); 602690210.1155/2019/6026902
