Laboratory of Infection Biology
The Laboratory of Infection Biology at the Institute of Microbiology of the Czech Academy of Sciences in Prague is seeking a talented and highly motivated Postdoctoral Researcher to join our team in the field of Structural Biology.
Position summary:
We invite applications for a postdoctoral position focused on the structural characterization of the tip complex of the type III secretion system injectisome in Gram-negative bacteria. This position is part of several ongoing, multidisciplinary projects led by Dr. Jana Kamanova.
Research description:
The type III secretion system injectisome is a key virulence factor used by many Gram-negative pathogens to inject effector proteins directly from the bacterial cytosol into host cells. This complex nanomachine consists of a cytosolic sorting platform, a basal body, a needle-like protrusion, and a translocon that forms a pore in the host cell membrane. In genera such as Bordetella and Aeromonas, the needle exhibits a unique filamentous tip, whose structure and interactions with other injectisome components are not well understood. Our lab explores these filamentous tips in Bordetella and Aeromonas genus using super-resolution fluorescence microscopy and genetic engineering. The selected candidate will visualize these structures in situ using electron microscopy. In addition, the selected candidate will purify the relevant proteins from native or heterologous expression systems and perform detailed structural and biochemical analyses.
Candidate profile:
We are seeking a postdoctoral researcher with a strong foundation in structural biology and a genuine interest in interdisciplinary research.
The ideal candidate will have:
- A PhD (or expected completion by August 1, 2025) in molecular biology, structural biology, biochemistry, or a related field
- Proven experience in protein purification using liquid chromatography
- Familiarity with biochemical and spectroscopic protein characterization and/or electron microscopy
- Experience in microbiology is advantageous but not essential
- Strong communication skills and proficiency in English (spoken and written)
- A collaborative attitude and enthusiasm for team-based research
We offer:
- A collaborative, multidisciplinary, and international research environment
- Involvement in ambitious biomedical projects
- Opportunities for professional development and skill enhancement
- 6 weeks of paid vacation annually (for full-time equivalent)
- Meaningfull and creative job
- Flexible working hours
- Contribution from the social security systém (Meal allowance, Cafeteria, MultiSport card, contribution to pension credit insurance, to vaccination, summer activities for children …)
Starting date: Summer 2025
Please submit your application online by July 23, 2025, as a single PDF file containing:
- A cover letter (max. 1000 words) outlining your interest in the position and your suitability.
- A CV including a list of publications and relevant experience.
- Contact details for at least two referees.
Please submit your application to email: and make sure to include this identification code: Postdoc.9.2025.MBU, as it is essential for processing your application.
Application deadline: 23/7/2025
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Anglická verze:
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Your personal data will be processed only to the necessary extent and for the duration of the recruitment process for the given position. All materials containing personal data of unsuccessful candidates will be deleted or shredded without undue delay, and at the latest within 6 months from the completion of the recruitment process.
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