Ing. Radim Osička, Ph.D.

Vedoucí vědecký pracovník

Publikace

Small protein blockers of human IL-6 receptor alpha inhibit proliferation and migration of cancer cells

Modification of the RTX domain cap by acyl chains of adapted length rules the formation of functional hemolysin pores.

Autoimmune amelogenesis imperfecta in patients with APS-1 and coeliac disease.

Toll-like receptor 4 and CD11b expressed on microglia coordinate eradication of Candida albicans cerebral mycosis

Kingella kingae RtxA toxin interacts with sialylated gangliosides

A conserved tryptophan in the acylated segment of RTX toxins controls their ?inf2/inf integrin–independent cell penetration

Early evolution of enamel matrix proteins is reflected by pleiotropy of physiological functions

Filamentous Hemagglutinin of Bordetella pertussis Does Not Interact with the ?2 Integrin CD11b/CD18

Kingella kingae RtxA Cytotoxin in the Context of Other RTX Toxins

Selective enhancement of the cell-permeabilizing activity of adenylate cyclase toxin does not increase virulence of bordetella pertussis

Different roles of conserved tyrosine residues of the acylated domains in folding and activity of RTX toxins

Bordetella Adenylate Cyclase Toxin Elicits Airway Mucin Secretion through Activation of the cAMP Response Element Binding Protein

Almost half of the RTX domain is dispensable for complement receptor 3 binding and cell-invasive activity of the Bordetella adenylate cyclase toxin

Simultaneous Determination of Antibodies to Pertussis Toxin and Adenylate Cyclase Toxin Improves Serological Diagnosis of Pertussis

Binding of Kingella kingae RtxA Toxin Depends on Cell Surface Oligosaccharides; but Not on beta(2) Integrins

Production of Highly Active Recombinant Dermonecrotic Toxin ofBordetella Pertussis

Acyltransferase-mediated selection of the length of the fatty acyl chain and of the acylation site governs activation of bacterial RTX toxins

Retargeting from the CR3 to the LFA-1 receptor uncovers the adenylyl cyclase enzyme?translocating segment ofBordetellaadenylate cyclase toxin

Distinct Spatiotemporal Distribution of Bacterial Toxin-Produced Cellular cAMP Differentially Inhibits Opsonophagocytic Signaling

Rapid Purification of Endotoxin-Free RTX Toxins

Residues 529 to 549 participate in membrane penetration and pore-forming activity of the Bordetella adenylate cyclase toxin