RNDr. Petr Novák, Ph.D.

Vedoucí vědecký pracovník

Publikace

Data-Independent Acquisition Represents a Promising Alternative for Fast Photochemical Oxidation of Proteins (FPOP) Samples Analysis

A Novel Monoallelic ALG5 Variant Causing Late-Onset ADPKD and Tubulointerstitial Fibrosis

Structural Characterization of Monoclonal Antibodies and Epitope Mapping by FFAP Footprinting

Isotopic Depletion Increases the Spatial Resolution of FPOP Top-Down Mass Spectrometry Analysis

Design of AsLOV2 domain as a carrier of light-induced dissociable FMN photosensitizer

An Unusual Two-Domain Thyropin from Tick Saliva: NMR Solution Structure and Highly Selective Inhibition of Cysteine Cathepsins Modulated by Glycosaminoglycans

Development of a PNGase Rc Column for Online Deglycosylation of Complex Glycoproteins during HDX-MS

Probing Antibody Structures by Hydrogen/Deuterium Exchange Mass Spectrometry

Top-Down Proteoform Analysis by 2D MS with Quadrupolar Detection

The rapid detection of procalcitonin in septic serum using immunoaffinity MALDI chips

Molecular structure of soluble vimentin tetramers

Multivalency of nucleosome recognition by LEDGF

Restored biosynthetic pathways induced by MSCs serve as rescue mechanism in leukemia cells after L-asparaginase therapy

A method for functionalization of an aromatic amino acid or a nucleobase

Experimental characterization of de novo proteins and their unevolved random-sequence counterparts

Preferred beta-lactone synthesis can explain high rate of false-negative results in the detection of OXA-48-like carbapenemases

Crystal structure of blue laccase BP76; a unique termite suicidal defense weapon.

Pre-invasion assessment on African invasive grasses revealed five new species of ergot fungi; Claviceps section Pusillae

Top-Down Detection of Oxidative Protein Footprinting by Collision-Induced Dissociation;Electron-Transfer Dissociation; and Electron-Capture Dissociation

In Vitro Evolution Reveals Noncationic Protein-RNA Interaction Mediated by Metal Ions

Utilization of Fast Photochemical Oxidation of Proteins and Both Bottom-up and Top-down Mass Spectrometry for Structural Characterization of a Transcription Factor-dsDNA Complex

Hydroxyl radical footprinting analysis of a human haptoglobin-hemoglobin complex

Early-onset pulmonary and cutaneous vasculitis driven by constitutively active SRC-family kinase HCK

Molecular Interactions Driving Intermediate Filament Assembly

Chitinase Chit62J4 essential for chitin processing by human microbiome bacterium clostridium paraputrificum J4

Early modification of cytochrome c by hydrogen peroxide triggers its fast degradation

Benefits of Ion Mobility Separation and Parallel Accumulation-Serial Fragmentation Technology on timsTOF Pro for the Needs of Fast Photochemical Oxidation of Protein Analysis

SAP domain forms a flexible part of DNA aperture in Ku70/80

LinX 2.0

LinX: A Software Tool for Uncommon Cross-Linking Chemistry

Studying Protein-DNA Interactions by Hydrogen/Deuterium Exchange Mass Spectrometry

Bacteriocin ASM1 is an O/S-diglycosylated; plasmid-encoded homologue of glycocin F

Targeting ERK-Hippo Interplay in Cancer Therapy

Three-Dimensional Printed Target Plates for Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry

Toward Increased Reliability; Transparency; and Accessibility in Cross-linking Mass Spectrometry

Photoinduced damage of AsLOV2 domain is accompanied by increased singlet oxygen production due to flavin dissociation

Addressing the Molecular Mechanism of Longitudinal Lamin Assembly Using Chimeric Fusions

Molecular Mechanism of LEDGF/p75 Dimerization

Influence of cross-linker polarity on selectivity towards lysine side chains

Proteomic Interactome of C. elegans Mediator Complex Subunit 28 (MDT-28) Reveals Predominant Association with a Restricted Set of Core Mediator Subunits and an Affinity to Additional Structural and Enzymatic Proteins

MatrixMotif

MS-Based Approaches Enable the Structural Characterization of Transcription Factor/DNA Response Element Complex

First Community-Wide; Comparative Cross-Linking Mass Spectrometry Study

Proteases Immobilization for In Situ Time-Limited Proteolysis on MALDI Chips

Binding of eIF3 in complex with eIF5 and eIF1 to the 40S ribosomal subunit is accompanied by dramatic structural changes

Reductant-Induced Free Radical Fluoroalkylation of Nitrogen Heterocycles and Innate Aromatic Amino Acid Residues in Peptides and Proteins

Ergochromes: Heretofore Neglected Side of Ergot Toxicity

Thiopurine intolerance-causing mutations in NUDT15 induce temperature-dependent destabilization of the catalytic site

The C-type lectin-like receptor Nkrp1b: Structural proteomics reveals features affecting protein conformation and interactions

Oligomeric Architecture of Mouse Activating Nkrp1 Receptors on Living Cells

The MEK-ERK-MST1 Axis Potentiates the Activation of the Extrinsic Apoptotic Pathway during GDC-0941 Treatment in Jurkat T Cells