Laboratoř imunoterapie
Vannucci LAB
Naše laboratoř se převážně zabývá studiem imunologických procesů nádorového mikroprostředí.
Studiem nádorového vývoje ve zvířecím experimentálním modelu sledujeme:
- Jaké důležité tkáňové struktury se přizpůsobují vývoji a růstu nádoru
- Jak jsou tyto změny závislé na lokálních změnách imunitního prostředí
- Jak toto prostředí podporuje růst nádoru nebo naopak jeho eliminaci
- Jak můžeme zvýšit nebo reaktivovat naši obranu proti nádorovému onemocnění včetně metastází a to jak lokálně (v nádoru) tak i systemicky (v celém organismu)

Služby pro veřejnost a spolupráce
• Haruki Okamura, Department of Tumor Cell Therapy, Hyogo Medical University, Japan (IL-18 and TME)
• Pierpaolo Ceci, Institute of Molecular Biology and Pathology, Italian National Research Council IBPM-CNR, Rome, Italy (tumor targeting theragnostic nanoconstructs)
• Francesco Novelli and Paola Cappello, Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy (inflammation and tumor associated fibrosis)
• Pierluigi Milella, Department of Science, University of Basilicata, Potenza, Italy (immuno-biological properties of plants’ extracts and ERASMUS+ students’ fellowships)
• Isaac Witz, The Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Science, Tel Aviv University, Tel Aviv, Israel (Tumor Microenvironment structure and immunity)
• Antonio Sica, Humanitas Clinical and Research Center, Milan, Italy (inflammation and TME)
• Baskar Saha, National Centre for Cell Science, Ganeshkhind, Pune, India (tumor immunogenicity and heterogeneity).
• Adriana Albini, European Institute of Oncology, Milan, Italy (tumor promoting inflammation, student exchanges)
• Francesco Merolla, Department of Medicine and Health Sciences „Vincenzo Tiberio“, University of Molise, Campobasso, Italy (pathology interpretation and AI applications)
• Paul Lehmann, Cellular Technology Ltd., Shaker Heights, OH, USA (advancing ELISPOT applications in immune cell responses)
• Giorgio Trinchieri, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA (cancer inflammation, immunity and microbiome)
• Antonio Gomez-Muñoz, Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country, Bilbao, Spain (C1P and cancer)
• Andriy Synytsya, Faculty of Food and Biochemical Technology, University of Chemistry and Technology in Prague, Prague, Czech Republic (immunomodulatory polysaccharides from algae and fungi)
• Daniel Hadraba, Laboratory of Biomathematics, Czech-BioImaging IPHYS, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic (advanced microscopy for tissue structural imaging)
• Andrew Harrison, Daniele Margarone, Pavel Blaha, Extreme Light Infrastructure ERIC (ELI ERIC)(high-intensity extremely short pulsing irradiation beams high-power laser generated for novel anticancer applications)
• Michal Babic, Institute of Macromolecular Chemistry, Czech Academy of Sciences, Prague, Czech Republic
Dr. L. Vannucci is:
• Member of the Peer Review Panel of international Experts at the Extreme Light Infrastructure ERIC European Research Infrastructure Consortium (ELI ERIC) European Commission Research Infrastructure of excellence (Dolny Brezany, CZ; Szeged, Hungary; Măgurele, Romania);
• Scientific member of the COMITES CZ (Italian commission in CZ belonging to the Italian Ministry of Foreign Affair, in connection with the Italian Embassy in Prague to interface from Italian residents in CZ and local institutions)
• Scientific Board member of Arpa Foundation, Pisa, Italy
• Scientific consultant for the Italian Embassy and Italian Institute of Culture in Prague

Naše publikace
A first-in-class non-cytotoxic nanocarrier based on a recombinant human ferritin boosts targeted therapy; chemotherapy and immunotherapy
Náš tým
Seznamte se s členy našeho týmu laboratoře imunoterapie
Vannucci Lab