Laboratory of Bacterial Virulence

Bacterial Virulence

ČERNÝ LAB

How can genetically identical bacteria act differently yet cooperate to cause one disease?

We aim to understand the molecular mechanisms underlying interactions between pathogenic bacteria and their host. As a model, we use Salmonella enterica serovar Typhimurium, which typically causes self-limiting diarrheal disease in humans but can also serve as a model for studying typhoid fever under laboratory conditions. Salmonella is one of the leading causes of diarrheal diseases worldwide and contributes to significant economic losses.