18. 6. 2025
Regulation of Gene Expression
Valášek Lab
My lab investigates the basics of protein synthesis and its regulation under stress, both at the general as well as gene-specific levels. Our research focuses on understanding how ribosomes recognize where to start and stop translation. We are also interested in tRNAs promoting stop codon readthrough and various alternative genetic codes, the detailed knowledge of which could be used in the treatment of various genetic diseases.
Focus of research
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Our mostly basic research is focused on finding out how the cell can decipher the DNA genetic code and, on the basis of a relatively simple key, translate – using a very complex mechanism – information from individual genes, as “data stores”, into proteins, as “executors” of the vast majority cellular functions. In addition, we are interested in how all this is regulated within the ever-changing conditions to which the cell is exposed and to which it must quickly respond by changing the repertoire of proteins it is currently synthesizing.
Our publications
Nature Structural & Molecular Biology. 2025; 32(3); 418-430
Guidelines for minimal reporting requirements; design and interpretation of experiments involving the use of eukaryotic \ndual gene expression reporters (MINDR)
Nature Structural & Molecular Biology. 2025; 32(January 13); 662-674
Ribosomal A-site interactions with near-cognate tRNAs drive stop codon readthrough
Our Team
Meet the members of our Gene Expression Regulation Laboratory team
Valášek Lab
