Laboratory of Regulation of Gene Expression - Mikrobiologický ústav AV ČR, v. v. i.

Regulation of Gene Expression

Valášek Lab

My lab investigates the basics of protein synthesis and its regulation under stress, both at the general as well as gene-specific levels. Our research focuses on understanding how ribosomes recognize where to start and stop translation. We are also interested in tRNAs promoting stop codon readthrough and various alternative genetic codes, the detailed knowledge of which could be used in the treatment of various genetic diseases.

Laboratory website

What’s new?

11. 3. 2025

When two do the same thing, it is not the same – even between scientists.

Focus of research

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Gene regulation

Translation

Reinitiation

Stop codon readthrough

Our mostly basic research is focused on finding out how the cell can decipher the DNA genetic code and, on the basis of a relatively simple key, translate – using a very complex mechanism – information from individual genes, as “data stores”, into proteins, as “executors” of the vast majority cellular functions. In addition, we are interested in how all this is regulated within the ever-changing conditions to which the cell is exposed and to which it must quickly respond by changing the repertoire of proteins it is currently synthesizing.