Nitrogen-Containing Flavonoids-Preparation and Biological Activity ACS Omega. 2024; 9(32); 34938-349502024 Hurtová M.Brdová D.Křížkovská B.Tedeschi G.Nejedlý T.Strnad O.Dobiasová S.Osifová Z.KroneislovÁ G.Lipov J.Valentová K.Viktorová J.Křen V.Zobrazit další (8) Laboratoř biotransformací10.1021/acsomega.4c04627
Quercetin protects cardiomyoblasts against hypertonic cytotoxicity by abolishing intracellular CaSUP2+/SUP elevations and mitochondrial depolarisation Biochemical Pharmacology. 2024; 222(April 2024); 1160942024 Dostál Z.Zholobenko A.Přichystalová H.Gottschalk B.Valentová K.Malli R.Modrianský M.Zobrazit další (2) Laboratoř biotransformací10.1016/j.bcp.2024.116094
Flavonoids as Aglycones in Retaining Glycosidase-Catalyzed Reactions: Prospects for Green Chemistry Journal of Agricultural and Food Chemistry. 2023; 71(41); 14890-149102023 Kotík M.Kulik N.Valentová K. Laboratoř biotransformací10.1021/acs.jafc.3c04389
Farmaceutický přípravek pro léčbu lékově rezistentních bakteriálních infekcí 2023 Viktorová J.Křen V.Holasová K.Macek T.Valentová K.Biedermann D.Dobiasová S.Zobrazit další (2) Laboratoř biotransformací
Inhibition of xanthine oxidase-catalyzed xanthine and 6-mercaptopurine oxidation by luteolin; naringenin; myricetin; ampelopsin and their conjugated metabolites Biomedicine & Pharmacotherapy. 2023; 167(NOV 2023); 1155482023 Balazs O.Dombi A.Zsido B.Hetenyi C.Valentová K.Vida R.Poor M.Zobrazit další (2) Laboratoř biotransformací10.1016/j.biopha.2023.115548
Combination of plant phenolics and isoquinolinium alkaloids protects gingival fibroblast and improves post-extraction healing after lower third molar extraction Biomedical Papers. 2023; 167(2); 131-1382023 Chytilová K.Galandaková A.Valentová K.Tvrdý P. Laboratoř biotransformací10.5507/bp.2021.055
Biotransformation of Natural Products and Phytochemicals: Metabolites; Their Preparation; and Properties International Journal of Molecular Sciences. 2023; 24(9); 80302023 Valentová K. Laboratoř biotransformací10.3390/ijms24098030
Metabolic profiling of silymarin constituents in urine and feces of healthy volunteers: A 90-day study Journal of Functional Foods. 2023; 100(Jan 23); 1053912023 Lněničková K.Vrba J.Kosina P.Papoušková B.Mekadim C.Mrázek J.Sova M.Sovová E.Valentová K.Křen V.Kouřilová P.Vrbková J.Ulrichová J.Zobrazit další (8) Laboratoř biotransformací10.1016/j.jff.2022.105391
Selectively Halogenated Flavonolignans—Preparation and Antibacterial Activity International Journal of Molecular Sciences. 2022; 23(23); 151212022 Hurtová M.Káňová K.Dobiasová S.Holasová K.Čáková D.Hoang L.Biedermann D.Kuzma M.Cvačka J.Křen V.Viktorová J.Valentová K.Zobrazit další (7) Laboratoř biotransformací10.3390/ijms232315121
Sulfation of Phenolic Acids: Chemoenzymatic vs. Chemical Synthesis International Journal of Molecular Sciences. 2022; 23(23); 151712022 Kolaříková V.Brodsky K.Petrásková L.Pelantová H.Cvačka J.Havlíček L.Křen V.Valentová K.Zobrazit další (3) Laboratoř biotransformací10.3390/ijms232315171
New Bacterial Aryl Sulfotransferases: Effective Tools for Sulfation of Polyphenols Journal of Agricultural and Food Chemistry. 2024; 72(40); 22208-222162024 Brodsky K.Petránková B.Petrásková L.Pelantová H.Křen V.Valentová K.Bojarová P.Zobrazit další (2) Laboratoř biotransformací10.1021/acs.jafc.4c06771
Interaction of myricetin; ampelopsin (dihydromyricetin); and their sulfate metabolites with serum albumin; cytochrome P450 (CYP2C9; 2C19; and 3A4) enzymes; and organic anion-transporting polypeptides (OATP1B1 and OATP2B1) Pharmacology Research & Perspectives. 2024; 12(5); e700212024 Dombi A.Kaci H.Valentová K.Bakos E.Ozvegy-Laczka C.Poór M.Zobrazit další (1) Laboratoř biotransformací10.1002/prp2.70021
The 2-aminoethyl diphenylborinate-based fluorescent method identifies quercetin and luteolin metabolites as substrates of Organic anion transporting polypeptides; OATP1B1 and OATP2B1 European Journal of Pharmaceutical Sciences. 2024; 196(1 May 2024); 1067402024 Kaci H.Bakos E.Needs P.Kroon P.Valentová K.Poor M.Ozvegy-Laczka C.Zobrazit další (2) Laboratoř biotransformací10.1016/j.ejps.2024.106740
Bacterial Aryl Sulfotransferases in Selective and Sustainable Sulfation of Biologically Active Compounds using Novel Sulfate Donors ChemSusChem. 2022; 15(18); e2022012532022 Brodsky K.Káňová K.Konvalinková D.Slámová K.Pelantová H.Valentová K.Bojarová P.Křen V.Petrásková L.Zobrazit další (4) Laboratoř biotransformací10.1002/cssc.202201253
Silybin and its congeners: from traditional medicine to molecular effects Natural Product Reports. 2022; 39(6); 1264-12812022 Křen V.Valentová K. Laboratoř biotransformací10.1039/d2np00013j
Interaction of Flavonoids with Zinc and Zinc-Containing Enzymes Journal of Agricultural and Food Chemistry. 2022; 70(20); 6134-61442022 Hrubša M.Tvrdý V.Kutý M.Valentová K.Křen V.Mladěnka P.Zobrazit další (1) Laboratoř biotransformací10.1021/acs.jafc.2c01446
Sulfated Phenolic Substances: Preparation and Optimized HPLC Analysis International Journal of Molecular Sciences. 2022; 23(10); 57432022 Petrásková L.Káňová K.Brodsky K.Hetman A.Petránková B.Pelantová H.Křen V.Valentová K.Zobrazit další (3) Laboratoř biotransformací10.3390/ijms23105743
Flavonolignans from silymarin modulate antibiotic resistance and virulence in Staphylococcus aureus Biomedicine & Pharmacotherapy. 2022; 149(May 2022); 1128062022 Holasová K.Křížkovská B.Hoang L.Dobiasová S.Lipov J.Macek T.Křen V.Valentová K.Ruml T.Viktorová J.Zobrazit další (5) Laboratoř biotransformací10.1016/j.biopha.2022.112806
Preparation of Synthetic and Natural Derivatives of Flavonoids Using Suzuki-Miyaura Cross-Coupling Reaction Molecules. 2022; 27(3); 9672022 Hurtová M.Biedermann D.Osifová Z.Cvačka J.Valentová K.Křen V.Zobrazit další (1) Laboratoř biotransformací10.3390/molecules27030967
Silymarin dehydroflavonolignans chelate zinc and partially inhibit alcohol dehydrogenase Nutrients. 2021; 13(12); 42382021 Tvrdý V.Hrubša M.Jirkovský E.Biedermann D.Kutý M.Valentová K.Křen V.Mladěnka P.Zobrazit další (3) Laboratoř biotransformací10.3390/nu13124238
Continuous diastereomeric kinetic resolution—silybins a and b Catalysts. 2021; 11(9); 11062021 Biedermann D.Hurtová M.Benada O.Valentová K.Biedermannová L.Křen V.Zobrazit další (1) Laboratoř biotransformací10.3390/catal11091106
Flavonols and Flavones In: TOMÁS-BARBERÁN; F.A.; GONZÁLEZ-SARRÍAS; A.; GARCÍA-VILLALBA; R.; eds. Dietary Polyphenols: Metabolism and Health Effects. Hoboken; New Jersey: John Willey and Sons Inc.; 2021; s. 163-1982021 Nunes dos Santos C.Menezes R.Carregosa D.Valentová K. Laboratoř biotransformací
Flavonolignans from silymarin do not intercalate into DNA: Rebuttal of data published in the paper J. Mol. Recognit. e2812 (2019) Journal of Molecular Recognition. 2021; 34(7); 28882021 Biedermann D.Hurtová M.Biedermannová L.Valentová K.Křen V. Laboratoř biotransformací10.1002/jmr.2888
Systematic review of pharmacokinetics and potential pharmacokinetic interactions of flavonolignans from silymarin Medicinal Research Reviews. 2021; 41(4); 2195-22462021 Tvrdý V.Pourová J.Jirkovský E.Křen V.Valentová K.Mladěnka P.Zobrazit další (1) Laboratoř biotransformací10.1002/med.21791
Data sharing in PredRet for accurate prediction of retention time: Application to plant food bioactive compounds Food Chemistry. 2021; 357(SEP 30 2021); 1297572021 Low D.Micheau P.Koistinen V.Hanhineva K.Abranko L.Rodriguez-Mateos A.da Silva A.van Poucke C.Almeida C.Andres-Lacueva C.Rai D.Capanoglu E.Barberan F.Mattivi F.Schmidt G.Gurdeniz G.Valentová K.Bresciani L.Petrásková L.Dragsted L.Philo M.Ulaszewska M.Mena P.Gonzalez-Dominguez R.Garcia-Villalba R.Kamiloglu S.de Pascual-Teresa S.Durand S.Wiczkowski W.Bronze M.Stanstrup J.Manach C.Zobrazit další (27) Laboratoř biotransformací10.1016/j.foodchem.2021.129757
Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network Advanced Drug Delivery Reviews. 2021; 171(APR 2021); 289-3312021 Vinarov Z.Abrahamsson B.Artursson P.Batchelor H.Berben P.Bernkop-Schnurch A.Butler J.Ceulemans J.Davies N.Dupont D.Flaten G.Fotaki N.Griffin B.Jannin V.Keemink J.Kesisoglou F.Koziolek M.Kuentz M.Mackie A.Melendez-Martinez A.McAllister M.Mullertz A.O'Driscoll C.Parrott N.Paszkowska J.Pávek P.Porter C.Reppas C.Stillhart C.Sugano K.Toader E.Valentová K.Vertzoni M.De Wildt S.Wilson C.Augustijns P.Zobrazit další (31) Laboratoř biotransformací10.1016/j.addr.2021.02.001
Dehydroflavonolignans from Silymarin Potentiate Transition Metal Toxicity In Vitro but Are Protective for Isolated Erythrocytes Ex Vivo Antioxidants. 2021; 10(5); 6792021 Lomozová Z.Tvrdý V.Hrubša M.Catapano M.Macáková K.Biedermann D.Kučera R.Křen V.Mladěnka P.Valentová K.Zobrazit další (5) Laboratoř biotransformací10.3390/antiox10050679
Interaction of silymarin components and their sulfate metabolites with human serum albumin and cytochrome P450 (2C9; 2C19; 2D6; and 3A4) enzymes Biomedicine & Pharmacotherapy. 2021; 138(JUN 2021); 1114592021 Faisal Z.Mohos V.Fliszar-Nyul E.Valentová K.Káňová K.Lemli B.Kunsagi-Mate S.Poor M.Zobrazit další (3) Laboratoř biotransformací10.1016/j.biopha.2021.111459
Cytoprotective Activity of Natural and Synthetic Antioxidants Antioxidants. 2020; 9(8); 7132020 Valentová K. Laboratoř biotransformací10.3390/antiox9080713
Sulfated Metabolites of Luteolin; Myricetin; and Ampelopsin: Chemoenzymatic Preparation and Biophysical Properties Journal of Agricultural and Food Chemistry. 2020; 68(40); 11197-112062020 Káňová K.Petrásková L.Pelantová H.Rybková Z.Malachová K.Cvačka J.Křen V.Valentová K.Zobrazit další (3) Laboratoř biotransformací10.1021/acs.jafc.0c03997
Multidrug Resistance Modulation Activity of Silybin Derivatives and Their Anti-Inflammatory Potential Antioxidants. 2020; 9(5); 4552020 Dobiasová S.Řehořová K.Kučerová D.Biedermann D.Káňová K.Petrásková L.Koucká K.Václavíková R.Valentová K.Ruml T.Macek T.Křen V.Viktorová J.Zobrazit další (8) Laboratoř biotransformací10.3390/antiox9050455
Identification of Human Sulfotransferases Active towards Silymarin Flavonolignans and Taxifolin Metabolites. 2020; 10(8); 3292020 Vrba J.Papoušková B.Kosina P.Lněničková K.Valentová K.Ulrichová J.Zobrazit další (1) Laboratoř biotransformací10.3390/metabo10080329
Simple and Rapid HPLC Separation and Quantification of Flavonoid; Flavonolignans; and 2;3-Dehydroflavonolignans in Silymarin Foods. 2020; 9(2); 1162020 Petrásková L.Káňová K.Biedermann D.Křen V.Valentová K. Laboratoř biotransformací10.3390/foods9020116
Defying Multidrug Resistance! Modulation of Related Transporters by Flavonoids and Flavonolignans Journal of Agricultural and Food Chemistry. 2020; 68(7); 1763-17792020 Chambers C.Viktorová J.Řehořová K.Biedermann D.Turková L.Macek T.Křen V.Valentová K.Zobrazit další (3) Laboratoř biotransformací10.1021/acs.jafc.9b00694
Biotransformation of Silymarin Flavonolignans by Human Fecal Microbiota Metabolites. 2020; 10(1); 292020 Valentová K.Havlík J.Kosina P.Papoušková B.Jaimes J.Káňová K.Petrásková L.Ulrichová J.Křen V.Zobrazit další (4) Laboratoř biotransformací10.3390/metabo10010029
Protective Effects of Dietary Polyphenols on Arterial Stiffness In: DIEDRICH; M.; ed. Proceedings. Basel: MDPI; 20192019 Hermans N.Steenput B.Roth L.De Meyer G.Nunes dos Santos C.Valentová K.Dambrova M.De Bruyne T.Zobrazit další (3) Laboratoř biotransformací10.3390/proceedings2019011040
The effect of silymarin flavonolignans and their sulfated conjugates on platelet aggregation and blood vessels ex vivo Nutrients. 2019; 11(10); 22862019 Pourová J.Applová L.Macáková K.Vopršalová M.Migkos T.Bentanachs R.Biedermann D.Petrásková L.Tvrdý V.Hrubša M.Karlíčková J.Křen V.Valentová K.Mladěnka P.Zobrazit další (9) Laboratoř biotransformací10.3390/nu11102286
2;3-Dehydroderivatives of Silymarin Flavonolignans: Prospective Natural Compounds for the Prevention of Chronic Diseases Proceedings. 2019; 11(1); 212019 Valentová K.Biedermann D.Křen V. Laboratoř biotransformací10.3390/proceedings2019011021
Antioxidant; Anti-Inflammatory; and Multidrug Resistance Modulation Activity of Silychristin Derivatives Antioxidants. 2019; 8(8); 3032019 Viktorová J.Dobiášová S.Řehořová K.Biedermann D.Káňová K.Šeborová K.Václavíková R.Valentová K.Ruml T.Křen V.Macek T.Zobrazit další (6) Laboratoř biotransformací10.3390/antiox8080303
Chemoenzymatic Synthesis and Radical Scavenging of Sulfated Hydroxytyrosol; Tyrosol; and Acetylated Derivatives Journal of Agricultural and Food Chemistry. 2019; 67(26); 7281-72882019 Begines P.Biedermann D.Valentová K.Petrásková L.Pelantová H.Maya I.Fernandez-Bolanos J.Křen V.Zobrazit další (3) Laboratoř biotransformací10.1021/acs.jafc.9b01065
Preparation of Retinoyl-Flavonolignan Hybrids and Their Antioxidant Properties Antioxidants. 2019; 8(7); 2362019 Chambers C.Biedermann D.Valentová K.Petrásková L.Viktorová J.Kuzma M.Křen V.Zobrazit další (2) Laboratoř biotransformací10.3390/antiox8070236
Glycosidase-Catalyzed Synthesis of Glycosyl Esters and Phenolic Glycosides of Aromatic Acids Advanced Synthesis & Catalysis. 2019; 361(11); 2627-26372019 Bassanini I.Kapešová J.Petrásková L.Pelantová H.Markošová K.Rebroš M.Valentová K.Kotík M.Káňová K.Bojarová P.Cvačka J.Turková L.Ferrandi E.Bayout I.Riva S.Křen V.Zobrazit další (11) Laboratoř biotransformací10.1002/adsc.201900259
The mechanisms of pharmacokinetic food-drug interactions – A perspective from the UNGAP group European Journal of Pharmaceutical Sciences. 2019; 134(JUN 15); 31-592019 Koziolek M.Alcaro S.Augustijns P.Basit A.Grimm M.Hens B.Hoad C.Jedamzik P.Madla C.Maliepaard M.Marciani L.Maruca A.Parrott N.Pávek P.Porter C.Reppas C.van Riet-Nales D.Rubbens J.Statelova M.Trevaskis N.Valentová K.Vertzoni M.Cepo D.Corsetti M.Zobrazit další (19) Laboratoř biotransformací10.1016/j.ejps.2019.04.003
Dietary Polyphenols Targeting Arterial Stiffness: Interplay of Contributing Mechanisms and Gut Microbiome-Related Metabolism Nutrients. 2019; 11(3); 5782019 De Bruyne T.Steenput B.Roth L.De Meyer G.Nunes dos Santos C.Valentová K.Dambrova M.Hermans N.Zobrazit další (3) Laboratoř biotransformací10.3390/nu11030578
Oxidation of flavonolignan silydianin to unexpected lactone-acid derivative Phytochemistry Letters. 2019; 30(APR); 14-202019 Biedermann D.Moravcová V.Valentová K.Kuzma M.Petrásková L.Císařová I.Křen V.Zobrazit další (2) Laboratoř biotransformací10.1016/j.phytol.2019.01.006
Isolated Silymarin Flavonoids Increase Systemic and Hepatic Bilirubin Concentrations and Lower Lipoperoxidation in Mice Oxidative Medicine and Cellular Longevity. 2019; 2019(1); 60269022019 Šuk J.Jašprová J.Biedermann D.Petrásková L.Valentová K.Křen V.Muchová L.Vítek L.Zobrazit další (3) Laboratoř biotransformací10.1155/2019/6026902
