doc. RNDr. Pavla Bojarová, Ph.D.

Vedoucí laboratoře

Publication

Expanding Rutinosidase Versatility: Acylated Quercetin Glucopyranosides as Substrates

Three-Step Enzymatic Remodeling of Chitin into Bioactive Chitooligomers

Biotransformation of free cyanide to formic acid by a cyanide hydratase-formamidase cascade reaction

Glycopolymer Inhibitors of Galectin-3 Suppress the Markers of Tissue Remodeling in Pulmonary Hypertension

Diaminocyclopentane – l-Lysine Adducts: Potent and selective inhibitors of human O-GlcNAcase

Synthesis and unexpected binding of monofluorinated N;N?-diacetylchitobiose and LacdiNAc to wheat germ agglutinin.

Glycomimetic inhibitors of tandem-repeat galectins: Simple and efficient

Highly functionalized diaminocyclopentanes: A new route to potent and selective inhibitors of human O-GlcNAcase

Galectin-targeting glycocalix[4]arenes can enter the cells

Lactose-Functionalized Carbosilane Glycodendrimers Are Highly Potent Multivalent Ligands for Galectin-9 Binding: Increased Glycan Affinity to Galectins Correlates with Aggregation Behavior.

Rutinosidase and other diglycosidases: Rising stars in biotechnology

Oligosaccharide Ligands of Galectin-4 and Its Subunits: Multivalency Scores Highly

Recent trends in the treatment of cyanide-containing effluents: Comparison of different approaches

Hesperidin; Hesperetin; Rutinose; and Rhamnose Act as Skin Anti-Aging Agents

Recent Progress in the Production of Cyanide-Converting Nitrilases-Comparison with Nitrile-Hydrolyzing Enzymes

Glycocalix[4]arenes and their affinity to a library of galectins: the linker matters

Advanced high-affinity glycoconjugate ligands of galectins

New Bacterial Aryl Sulfotransferases: Effective Tools for Sulfation of Polyphenols

FLUORINE-INDUCED STRENGTHENING OF C?H/? INTERACTION AS AN IMPORTANT DRIVING FORCE BEHIND THE RECOGNITION OF FLUORINATED DISACHARIDES BY WHEAT GERM AGGLUTININE

Structural Properties of Deoxyfluorinated Analogues of N-acetyllactosamine; N; N’-diacetyllactosamine and; N; N’-diacetylchitobiose

Mutation Hotspot for Changing the Substrate Specificity of beta-N-Acetylhexosaminidase: A Library of GlcNAcases

Bacterial Aryl Sulfotransferases in Selective and Sustainable Sulfation of Biologically Active Compounds using Novel Sulfate Donors

Diaminocyclopentane-derived O-GlcNAcase inhibitors for combating tau hyperphosphorylation in Alzheimer’s disease

Methods of in vitro study of galectin-glycomaterial interaction

Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars

Hypertransglycosylating Variants of the GH20 beta-N-Acetylhexosaminidase for the Synthesis of Chitooligomers

Engineered Glycosidases for the Synthesis of Analogs of Human Milk Oligosaccharides

Glycopolymers Decorated with 3-O-Substituted Thiodigalactosides as Potent Multivalent Inhibitors of Galectin-3

2-Acetamido-2-deoxy-d-glucono-1;5-lactone Sulfonylhydrazones: Synthesis and Evaluation as Inhibitors of Human OGA and HexB Enzymes

Reversible Lectin Binding to Glycan-Functionalized Graphene

Deoxyfluorination as a Promising Synthetic Approach to Selective Carbohydrate-based Galectin Inhibitors.

Application Potential of Cyanide Hydratase from Exidia glandulosa: Free Cyanide Removal from Simulated Industrial Effluents

Mutagenesis of Catalytic Nucleophile of beta-Galactosidase Retains Residual Hydrolytic Activity and Affords a Transgalactosidase

Advanced glycosidases as ingenious biosynthetic instruments

Enzymatic detoxification of cyanide using cyanide hydratases

Selectively Deoxyfluorinated N-Acetyllactosamine Analogues as 19F NMR Probes to Study Carbohydrate-Galectin Interactions.

Immunoprotective neo-glycoproteins: Chemoenzymatic synthesis of multivalent glycomimetics for inhibition of cancer-related galectin-3

Interaction between Galectin-3 and Integrins Mediates Cell-Matrix Adhesion in Endothelial Cells and Mesenchymal Stem Cells

Cross-linking effects dictate the preference of galectins to bind LacNAc-decorated HPMA copolymers

Growth Factors VEGF-A(165) and FGF-2 as Multifunctional Biomolecules Governing Cell Adhesion and Proliferation

Access to both anomers of rutinosyl azide using wild-type rutinosidase and its catalytic nucleophile mutant

Transglycosidase activity of glycosynthase-type mutants of a fungal GH20 beta-N-acetylhexosaminidase

How Site-Directed Mutagenesis Boosted Selectivity of a Promiscuous Enzyme

Dual Substrate Specificity of the Rutinosidase fromAspergillus nigerand the Role of Its Substrate Tunnel

Regioselective 3-O-Substitution of Unprotected Thiodigalactosides: Direct Route to Galectin Inhibitors

Biocatalysis: ´A Jack of all Trades …´

Glycopolymers for efficient inhibition of galectin-3: in vitro proof of efficacy using suppression of T lymphocyte apoptosis and tumor cell migration

A novel enzymatic tool for transferring GalNAc moiety onto challenging acceptors

Acceptor Specificity of ?-N-Acetylhexosaminidase from Talaromyces flavus: A Rational Explanation

beta-N-Acetylhexosaminidases-the wizards of glycosylation

Glycosidase-Catalyzed Synthesis of Glycosyl Esters and Phenolic Glycosides of Aromatic Acids

HPMA copolymers decorated with saccharide ligands: the architecture of spacer matters

Selective Beta-N-acetylhexosaminidase from Aspergillus versicolor—a tool for producing bioactive carbohydrates

Bioproduction of Quercetin and Rutinose Catalyzed by Rutinosidase: Novel Concept of´Solid State Biocatalysis´

The beta-N-Acetylhexosaminidase in the Synthesis of Bioactive Glycans: Protein and Reaction Engineering

Galectin-Carbohydrate Interactions in Biomedicine and Biotechnology